The combined supplementation of omega-3 fatty acids and probiotics decreased the levels of serum polyamines in experimental colitis

Polyamines play an important role in the maintenance of intestinal permeability. Therefore we aimed to determine effects probiotics and omega 3 fatty acids on serum polyamine levels colitis. Fifty BALB/c mice were randomly grouped as normal, colitis with no treatment applied, treated by (VSL#3), omega-3, both omega-3. Experimental was induced injection 200 mg/kg 2,4-Dinitrobenzenesulfonic acid (DNBS). The probiotic omega-3 supplements applied daily oral gavage. Serum measured high performance liquid chromatography (HPLC). In each group, polyamines are highest spermidine least spermine. Bowel inflammation experimentally resulted lower concentrations. supplemented group significant decreases observed for spermine (p<0.001), while changes obtained putrescine. Combined supplementation 10 days significantly decreased spermidine.